Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Comparison of Paraben Stability in Human and Rat Skin

Author(s): Heather M. Harville, Richard Voorman, Jeffery J. Prusakiewicz.

Abstract:

Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.

Keywords: Paraben, esterase, skin, epidermal drug metabolism

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [17 - 21]
Pages: 5
DOI: 10.2174/187231207779814300