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Drug Metabolism Letters

Editor-in-Chief

ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Author(s): Thomas K. H. Chang, Jie Chen and Chia-Ting Yu

Volume 1, Issue 1, 2007

Page: [13 - 16] Pages: 4

DOI: 10.2174/187231207779814337

Abstract

Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

Keywords: CYP1A1, CYP1A2, cytochrome P450, piceatannol, trans-resveratrol


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