Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Author(s): Thomas K. H. Chang, Jie Chen, Chia-Ting Yu.

Abstract:

Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

Keywords: CYP1A1, CYP1A2, cytochrome P450, piceatannol, trans-resveratrol

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2007
Page: [13 - 16]
Pages: 4
DOI: 10.2174/187231207779814337