P2O5 Promoted One-Pot Synthesis of 3-aminoimidazo[1,2-a]pyridines under Solvent-Free Conditions

Author(s): Ebrahim Soleimani, Mojtaba Taran, Mohsen Zainali, Shahram Lotfi.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 3 , 2012

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A facile, efficient and environment-friendly protocol for the synthesis of 3-aminoimidazo[1,2-a]pyridines has been developed by one-pot condensation of 2-aminopyridine, aromatic aldehyde and alkyl or aryl isocyanide in the presence of P2O5 as catalyst under solvent-free conditions at room temperature. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, high yield, easy purification, and economic availability of the catalyst.

Keywords: Imidazo[1,2-a]pyridine, P2O5, 2-Aminopyridine, Isocyanide, pyridines, pyrimidines, montmorillonite, benzaldehyde, aminopyridnes, pentoxide

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Article Details

Year: 2012
Page: [198 - 201]
Pages: 4
DOI: 10.2174/157017812800167411
Price: $58

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