A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-butyl dicarbonate using magnetically recoverable γ-Fe2O3@SiO2 nanoparticles is reported. The catalyst can be easily recovered and recycled without a significant loss in the catalytic activity. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were obsereved.
Keywords: (Boc)2O, chemoselective, magnetic nanoparticles, protection, recycling, biotechnology, tert-butoxycarbonyl, amine, magnetic field, nanocatalysis
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