One pot three-component reaction of 2-amino pyridines, aldehydes and isocyanides in the presence of silicasupported perchloric acid (HClO4-SiO2), produces 3-aminoimidazo[1,2-a] pyridines in excellent yields. The reaction time is short and work up of reaction is very easy. New compounds were identified by IR, 1H NMR, 13C NMR and Mass spectrum.
Keywords: 3-Aminoimidazo[1,2-a] pyridine, isocyanide, multi-component reaction, silica-supported perchloric acid (HClO4-SiO2), annulanes, calcium, heterocycles, medicinal chemistry, pyrazine, aldehydes
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