Efficient Synthesis of 3-Aminoimidazo[1,2-a] Pyridines Using Silica-Supported Perchloric Acid (HClO4-SiO2) as a Novel Heterogenous Catalyst

Author(s): Azizollah Habibi, Zahra Tarameshloo, Shahnaz Rostamizadeh, Ali M. Amani.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 3 , 2012

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One pot three-component reaction of 2-amino pyridines, aldehydes and isocyanides in the presence of silicasupported perchloric acid (HClO4-SiO2), produces 3-aminoimidazo[1,2-a] pyridines in excellent yields. The reaction time is short and work up of reaction is very easy. New compounds were identified by IR, 1H NMR, 13C NMR and Mass spectrum.

Keywords: 3-Aminoimidazo[1,2-a] pyridine, isocyanide, multi-component reaction, silica-supported perchloric acid (HClO4-SiO2), annulanes, calcium, heterocycles, medicinal chemistry, pyrazine, aldehydes

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Article Details

Year: 2012
Page: [155 - 159]
Pages: 5
DOI: 10.2174/157017812800167439
Price: $65

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