Thrombolysis in Ischemic Stroke: Focus on New Treatment Strategies
Rocco S. Calabro, Giuseppe Gervasi, Placido Bramanti and Anna Cavallini
Affiliation: IRCCS Centro Neurolesi “Bonino-Pulejo”, S.S.113 via Palermo, Cda Casazza, 98124 Messina, Italy.
Stroke is the third leading cause of death and the main cause of permanent disability in western countries. Reperfusion within 3 hours of symptoms-onset is the most beneficial of all therapeutic strategies for acute ischemic stroke. Alteplase has been the first thrombolytic treatment approved by FDA. However, its use is still limited to specific patient subgroups and may be complicated by severe side effects, including massive cerebral hemorrhages. This review is aimed at investigating the current and future treatment strategies in ischemic stroke, including new fibrinolytic drugs, sonothrombolysis, mechanical clot retrievals, and recent patents.
Keywords: Bridging, intra-arterial thrombolysis, intravenous thrombolysis, mechanical clot retrieval, patents thrombolytic agents, rtPA, sonothrombolysis, Acute Ischemic Stroke, Coagulation, Fibrinolysis
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