Abstract
Mesenchymal stem cells (MSCs) are multipotent cells that have the capability of differentiating into several different cells such as osteoblasts (bone), chondrocytes (cartilage), adipocytes (fat), myocytes (muscle) and tenocytes (tendon). In this review we highlight the different regulators which determine the lineage a particular MSC will differentiate into. Mesenchymal stem cells are increasingly being used in tissue regeneration and repair. Strict regulation of differentiation of MSCs is essential for a positive outcome of the particular tissue treated with MSCs, especially due to the fact that capacity to differentiate decreases with increasing age of the donor.
Keywords: Adipocytes, chondrocytes, differentiation, mesenchymal stem cells, myocytes, osteoblasts, tenocytes, Orthopaedic Surgery, bone tissue engineering, Gene transfer
Current Stem Cell Research & Therapy
Title: Regulation of Differentiation of Mesenchymal Stem Cells into Musculoskeletal Cells
Volume: 7 Issue: 2
Author(s): Gopiga Thanabalasundaram, Nikita Arumalla, Hiteshkumar D. Tailor and Wasim S. Khan
Affiliation:
Keywords: Adipocytes, chondrocytes, differentiation, mesenchymal stem cells, myocytes, osteoblasts, tenocytes, Orthopaedic Surgery, bone tissue engineering, Gene transfer
Abstract: Mesenchymal stem cells (MSCs) are multipotent cells that have the capability of differentiating into several different cells such as osteoblasts (bone), chondrocytes (cartilage), adipocytes (fat), myocytes (muscle) and tenocytes (tendon). In this review we highlight the different regulators which determine the lineage a particular MSC will differentiate into. Mesenchymal stem cells are increasingly being used in tissue regeneration and repair. Strict regulation of differentiation of MSCs is essential for a positive outcome of the particular tissue treated with MSCs, especially due to the fact that capacity to differentiate decreases with increasing age of the donor.
Export Options
About this article
Cite this article as:
Thanabalasundaram Gopiga, Arumalla Nikita, D. Tailor Hiteshkumar and S. Khan Wasim, Regulation of Differentiation of Mesenchymal Stem Cells into Musculoskeletal Cells, Current Stem Cell Research & Therapy 2012; 7 (2) . https://dx.doi.org/10.2174/157488812799218974
DOI https://dx.doi.org/10.2174/157488812799218974 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Myelodysplastic/Myeloproliferative Neoplasms
Current Cancer Therapy Reviews Role of the Non-Receptor Tyrosine Kinase Fes in Cancer
Current Medicinal Chemistry Aberrant Expression of MicroRNAs in B-cell Lymphomas
MicroRNA Docking Studies of Glutamine Valproic Acid Derivative (S)-5- amino-2-(heptan-4-ylamino)-5-oxopentanoic Acid (Gln-VPA) on HDAC8 with Biological Evaluation in HeLa Cells
Anti-Cancer Agents in Medicinal Chemistry Anti-CD30 Human IL-2 Fusion Proteins Display Strong and Specific Cytotoxicity In Vivo
Current Drug Targets The Ovary Feels Fine when Paracrine and Autocrine Networks Cooperate with Gonadotropins in the Regulation of Folliculogenesis
Current Pharmaceutical Design Combination Therapy of Cisplatin and other Agents for Osteosarcoma: A Review
Current Cancer Therapy Reviews Pharmacogenetics of Target Genes Across Doxorubicin Disposition Pathway: A Review
Current Drug Metabolism Editorial [Hot topic: New and Emerging Drug Targets for the Treatment of Hematological Malignancies (Guest Editors: Dr. Linda J. Bendall)]
Current Drug Targets Chronic Inflammation and Cancer: The Role of Endothelial Dysfunction and Vascular Inflammation
Current Pharmaceutical Design Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery
Current Drug Targets Current Gene Therapy Strategies for Colorectal Cancer
Current Genomics Novel Marine-Derived Anti-Cancer Agents
Current Pharmaceutical Design A Dual Role for Sirtuin 1 in Tumorigenesis
Current Pharmaceutical Design Improved Immunotoxins with Novel Functional Elements
Current Pharmaceutical Design Monitoring T Cell Responses to Cancer Immunotherapy: Can We Now Identify Biomarkers Predicting Patients Who will be Responders
Current Cancer Therapy Reviews Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting
Current Pharmaceutical Design Transmission and Immunopathogenesis of FIV in Cats as a Model for HIV
Current HIV Research Production of Lentivectors for Clinical Use
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Recommendations for Severe Hypertriglyceridemia Treatment, are there New Strategies?
Current Vascular Pharmacology