Immunomodulatory Properties of ES-62, a Phosphorylcholine - Containing Glycoprotein Secreted by Acanthocheilonema viteae

Author(s): Lamyaa Al-Riyami, William Harnett.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 12 , Issue 1 , 2012

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Filarial nematodes are parasites that have the ability to persist in their hosts for extended periods of time due to the employment of various mechanisms to divert or down-regulate the hosts immune responses. One of these mechanisms is the production of immunomodulatory excretory-secretory (ES) products. This review will discuss the properties of one such product, ES-62, which over the years, has been shown to interact with and modulate the activities of a variety of cells of the immune system including B and T lymphocytes, dendritic cells, macrophages and mast cells. Overall, ES-62 diverts the immune system towards an anti-inflammatory phenotype and consistent with this it has been shown to have therapeutic potential in models of inflammatory disease associated with autoimmunity and allergy.

Keywords: Signal transduction, ES-62, filarial nematode, immunomodulation, immunomodulatory, autoimmunity, Allergy, excretory-secretory, glucosamine-labelled ES-62, N- glycosidase, anti-inflammatory

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Article Details

Year: 2012
Page: [45 - 52]
Pages: 8
DOI: 10.2174/187153012799278893

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