Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?

Author(s): Fabrizio Bruschi, Lorena Chiumiento.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 12 , Issue 1 , 2012

Become EABM
Become Reviewer

Abstract:

This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.

Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 1
Year: 2012
Page: [4 - 15]
Pages: 12
DOI: 10.2174/187153012799279081

Article Metrics

PDF: 32