Abstract
This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?
Volume: 12 Issue: 1
Author(s): Fabrizio Bruschi and Lorena Chiumiento
Affiliation:
Keywords: Eosinophils, escape mechanisms, IgE, immunomodulation, mast cells, T helper 1, T helper 2, trichinellosis, parasite, Trichinella, T. spiralis, T. nativa, T. murrelli, Type II diabetes
Abstract: This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
Export Options
About this article
Cite this article as:
Bruschi Fabrizio and Chiumiento Lorena, Immunomodulation in Trichinellosis: Does Trichinella Really Escape the Host Immune System?, Endocrine, Metabolic & Immune Disorders - Drug Targets 2012; 12 (1) . https://dx.doi.org/10.2174/187153012799279081
DOI https://dx.doi.org/10.2174/187153012799279081 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Unravelling the Role of Infectious Agents in the Pathogenesis of Human Autoimmunity: The Hypothesis of the Retroviral Involvement Revisited
Current Molecular Medicine Neuropsychiatric Disturbances in Alzheimer’s Disease: What Have We Learned from Neuropathological Studies?
Current Alzheimer Research Parkinsons Disease and Obsessive-Compulsive Phenomena: A Systematic Review
Current Psychiatry Reviews Gene Therapy and Targeted Toxins for Glioma
Current Gene Therapy Galectin-9 in Cancer Therapy
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Hendra and Nipah Viruses: Pathogenesis and Therapeutics
Current Molecular Medicine Therapeutic Opportunities for Trophic Factors in Brain Inflammation
Current Pharmaceutical Analysis A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Ebola Virus Altered Innate and Adaptive Immune Response Signalling Pathways: Implications for Novel Therapeutic Approaches
Infectious Disorders - Drug Targets Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades
Current Pharmaceutical Design Role of CNS Transporters in the Pharmacotherapy of HIV-1 Associated Neurological Disorders
Current Pharmaceutical Design HIV-2 Infection and Chemokine Receptors Usage - Clues to Reduced Virulence of HIV-2
Current HIV Research Host-Pathogen Interactions in Latent Mycobacterium tuberculosis Infection: Identification of New Targets for Tuberculosis Intervention
Endocrine, Metabolic & Immune Disorders - Drug Targets Antitumor and Antiviral Activity of Pentacyclic Triterpenes
Mini-Reviews in Organic Chemistry Acyclovir in the Treatment of Herpes Viruses – A Review
Current Medicinal Chemistry Intrinsic Disorder and Function of the HIV-1 Tat Protein
Protein & Peptide Letters The Aftermath of Childhood Sexual Abuse: A Case Report and Review of the Literature
Adolescent Psychiatry Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics
Current Topics in Medicinal Chemistry Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme
Current Medicinal Chemistry Microglial Activation and its Implications in the Brain Diseases
Current Medicinal Chemistry