Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and In Vitro Antibacterial Screening of some New 2,4,6-Trisubstituted-1,3,5-Triazine Derivatives

Author(s): Ravi Bhushan Singh, Nirupam Das, Srabanti Jana, Aparoop Das.

Abstract:

With an objective to evaluate the antibacterial activity of triazine derivatives, a series of 2,4,6-trisubstituted- 1,3,5-triazine were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The minimum inhibitory concentration (MIC) of the compounds that displayed favourable zone of inhibition was determined by broth microdilution method. Derivatives with morpholinyl substituent (4a and 4i) demonstrated good in vitro activities against Gram-positive organisms, whereas two of the compound bearing a diethylamino side chain exhibited moderate (4e) to broad spectrum (4j) activity comparable to streptomycin. The promising activity of the latter maybe attributed to the substitution of electron releasing group at para position of phenyl rings.

Keywords: Antibacterial activity, Cyanuric chloride, 1,3,5-triazine, Morpholine, Minimum inhibitory concentration, Staphylococcus aureus, methicillin-resistant, Antimicrobial resistance, side-effect profile, antimalarial, Bacillus subtilis, antileishmanial, Mycobacterium tuberculosis, chromatography, Electron Impact Mass Spectrometer

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2012
Page: [316 - 321]
Pages: 6
DOI: 10.2174/157018012799129936
Price: $58