Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents

Author(s): M. S.R. Murty, Kesur R. Ram, Rayudu Venkateswara Rao, J. S. Yadav, Janapala Venkateswara Rao, L. R. Velatooru.

Abstract:

A series of 3-[3-[4-(Substituted)-1-cyclicamine]propyl]thio-5-substituted[1,2,4]triazoles (8a-j) were synthesized with good yields starting from corresponding carboxylic acids. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Three compounds had shown good anticancer activity. The triazole derivatives, 8i and 8j were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinants of their biological activity.

Keywords: 1,2,4-Triazoles, Acid hydrazides, Piperazines, Anticancer, S-alkylated-3-mercapto-1,2,4-triazole Derivatives, Cyclic Amine Moiety, Cancer drug discovery, side-effect profile, CNS, piperazine derivatives, Cytotoxicity Studies, MTT, cytotoxicity, catalytic

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2012
Page: [276 - 281]
Pages: 6
DOI: 10.2174/157018012799129882
Price: $58