Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates

Author(s): Ahmed Kamal, B. Ashwini Kumar, Paidakula Suresh.

Abstract:

A series of pyridylimidazolidinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates have been synthesized and evaluated for their DNA binding ability and cytotoxicity. These conjugates exhibited significant DNA binding ability and potent anticancer activity with GI50 values in the range of 0.2 – 3 μ M.

Keywords: Pyrrolobenzodiazepine, Pyridylimidazolidinone, DNA binding ability, Cytotoxicity, Streptomyces species, antibiotics, S-configuration, arylimidazolidinone, DNA INTERACTIONS, pyridylimidazolidinone-PBD conjugates, RED100-RESTRICTION ENDONUCLEASE DIGES-TION ASSAY, non-covalent interactions, ANTICANCER ACTIVITY, DNA binding

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2012
Page: [234 - 241]
Pages: 8
DOI: 10.2174/157018012799129927
Price: $58