Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates

Title: Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates

Volume: 9 Issue: 3

Author(s): Ahmed Kamal, B. Ashwini Kumar and Paidakula Suresh

Affiliation:

Keywords: Pyrrolobenzodiazepine, Pyridylimidazolidinone, DNA binding ability, Cytotoxicity, Streptomyces species, antibiotics, S-configuration, arylimidazolidinone, DNA INTERACTIONS, pyridylimidazolidinone-PBD conjugates, RED100-RESTRICTION ENDONUCLEASE DIGES-TION ASSAY, non-covalent interactions, ANTICANCER ACTIVITY, DNA binding

Abstract: A series of pyridylimidazolidinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates have been synthesized and evaluated for their DNA binding ability and cytotoxicity. These conjugates exhibited significant DNA binding ability and potent anticancer activity with GI50 values in the range of 0.2 – 3 μ M.

Cite this article as:

Kamal Ahmed, Ashwini Kumar B. and Suresh Paidakula, Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129927