Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages

Author(s): Anna M. Varizhuk, Svetlana V. Kochetkova, Alexander U. Fedotov, Natalia A. Kolganova, Edward N. Timofeev, Vladimir L. Florentiev.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 2 , 2012

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Abstract:

Oligonucleotide analogs with L- and D-lysine residues incorporated in internucleotide linkages were synthesized and their affinity toward complementary DNA was studied. Stability of the duplexes formed by the modified oligonucleotides and their wild-type complements appeared to be close to that of the isosequential unmodified duplex, oligonucleotides carrying D-lysine residues forming generally more stable duplexes than L-lysine derivatives.

Keywords: Analogs, hybridization, oligonucleotides, peptide internucleotide linkages, synthesis, thermal stability, duplexes, triplexes, epimerization, dichloromethane

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2012
Page: [106 - 113]
Pages: 8
DOI: 10.2174/157017812800221799
Price: $65

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