Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Neurotuberculosis: An Overview

Author(s): Murilo Gimenes Rodrigues, Antonio Jose da Rocha, Marcelo Rodrigues Masruha, Thais Soares Cianciarullo Minett.

Abstract:

Although pulmonary tuberculosis is the most common form of this disease, neurotuberculosis is more severe and presents higher morbidity and mortality. Its diagnosis continues to challenge physicians all over the world. Contributing to this fact is the nonspecificity of its clinical manifestations, the low density of bacilli in the cerebrospinal fluid (CSF), and the delayed recovery of Mycobacterium tuberculosis through culture techniques. Thus, the diagnosis is largely based on suspicious symptoms, and the prognosis is directly related to the stage of the disease at the beginning of treatment. Even thought there is no consensus regarding the best therapeutic regimen, the WHO recommends using the same regimen used for pulmonary tuberculosis with a longer treatment time. It is important to note that in most cases, the doctor will not have a definite diagnosis at the beginning of the treatment. However, this should not delay the initiation of therapy. A delay in initiating treatment, in most cases, is directly associated with a poor prognosis. This review gives an overview of the current state of the neurotuberculosis research. It covers the epidemiological aspects of the infection, pathogenesis, principal clinical presentations, diagnosis highlighting neuroimaging, where a series of imaging are presented, prognosis, prevention and therapeutic regimens.

Keywords: central nervous system, meningitis, diagnosis, Tuberculosis, treatment, miliary tuberculosis, immunodeficiency virus (HIV), central nervous system (CNS), Tuberculous meningitis ™

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2011
Page: [246 - 260]
Pages: 15
DOI: 10.2174/1871524911106040246
Price: $58