Fat-Soluble Vitamins Release Based on Clinoptilolite Zeolite as an Oral Drug Delivery System

Mehdi      Rahimi; Hamid      Mobedi; Aliasghar      Behnamghader; Alireza      Nateghi Baygi; Houri      Mivehchi; Esmaeil      Biazar

Abstract

The purpose of this research was to study the effect of zeolite powder, with particles size range between 53 and 1180 μm, on the stability and release of vitamins A, D3 and E. Zeolite type, chemical and morphological features were studied using SEM and XRF. High performance liquid chromatography was used to investigate the extracted vitamins from zeolite powder. The powder emanating from natural Iranian zeolite was first plunged into each saturated solution of vitamins A, D3 and E. The powders were then taken in laboratory condition for 2 h, 1, 2, 3 and 4 weeks at room temperature. The amount of the extracted vitamin constantly decreased with time in the control sample (without zeolite powder), whereas it remained steady in the zeolite containing sample. The amount of stable vitamin in ambient environment after 4 weeks was higher than the control sample due to the zeolite with particles size range between 710 and 850 μm. For simulated gastrointestinal pH, the amount of release from the sample with zeolite was also more than the control sample. Based on the results obtained from HPLC experiments, zeolite powder enhanced the stability of the system in acidic pH and increased the amount of vitamins released in gastrointestinal condition.

Keywords: Natural clinoptilolite, Fat-soluble vitamins, Stability, Drug delivery, Zeolites, aluminosilicates, cation exchange capacity (CEC), lipid-soluble antioxidants, Quantitative Vitamins Analysis, Anzymite, Vitamin A, DSM, HPLC, XRF analysis