Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Acyl Hydrazides: Potent Antioxidants

Author(s): Khalid Mohammed Khan, Mubeen Rani, Nida Ambreen, Asma Ejaz, Shahnaz Perveen, Syed Moazzam Haider, Mohammad Iqbal Choudhary, Wolfgang Voelter.

Abstract:

Twenty-eight acyl hydrazides (1-28) are subjected for nitric oxide scavenging activities and their structureactivity relationship (SAR) is established. Compounds 1-28 showed a varying degree of activity having IC50 values in the range of 9.1 ± 6.5 - 231.1 μM. It was found that twenty-five (25) out of twenty-eight (28) compounds, showed an excellent nitric oxide scavenging activity. It was observed that the activity mainly depends on the substitution on acyl hyrazide moiety. 3-Propylpyrozole-5-carbohydrazide (27) was found to be the most active in the series with an IC50 value of 9.1 μM. Thus, compound 27 may serve as a lead compound for further development as potent antioxidant agent.

Keywords: Acyl hydrazides, Free radicals, Reactive oxygen species (ROS), Nitric oxides scavengers, Antioxidant, Lead molecules, peroxynitrite, tonic relaxation, antitumor, antiglycation, antituberculosis, Nitroprusside sodium, heterocyclic, radical-scavenging, antimicrobial, conventional synthetic methods

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2012
Page: [135 - 139]
Pages: 5
DOI: 10.2174/157018012799079798
Price: $58