Abstract
The antimycobacterial activity of new 18 7-chloroquinoline derivatives, obtained from 4,7-dichloroquinoline, was evaluated against 15 Mycobacterium spp among standardized and clinical isolates using the MTT susceptibility test to obtain minimum inhibitory concentration values (MIC, μg/mL). The results suggested that 7-chloroquinoline compounds are useful leads for new anti-TB drug development. The most active compounds exhibited moderate activity with 16 μg/mL MIC values for all tested microorganisms.
Keywords: 7-Chloroquinoline derivatives, Synthesis, MDR-TB, Antimycobacterial activity, Tuberculosis (TB), Mycobacterium tuberculosis, human immunodeficiency virus (HIV), rifampin (RMP), isonicotinylhydrazine, INH, Heterocyclic systems, quinine, chloroquine, primaquine, amodiaquine
Letters in Drug Design & Discovery
Title: In Vitro Antimycobacterial Activity of New 7-Chloroquinoline Derivatives
Volume: 9 Issue: 2
Author(s): Juan Bueno, Fernando A. Rojas Ruiz, Santiago Villabona Estupinan and Vladimir V. Kouznetsov
Affiliation:
Keywords: 7-Chloroquinoline derivatives, Synthesis, MDR-TB, Antimycobacterial activity, Tuberculosis (TB), Mycobacterium tuberculosis, human immunodeficiency virus (HIV), rifampin (RMP), isonicotinylhydrazine, INH, Heterocyclic systems, quinine, chloroquine, primaquine, amodiaquine
Abstract: The antimycobacterial activity of new 18 7-chloroquinoline derivatives, obtained from 4,7-dichloroquinoline, was evaluated against 15 Mycobacterium spp among standardized and clinical isolates using the MTT susceptibility test to obtain minimum inhibitory concentration values (MIC, μg/mL). The results suggested that 7-chloroquinoline compounds are useful leads for new anti-TB drug development. The most active compounds exhibited moderate activity with 16 μg/mL MIC values for all tested microorganisms.
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Cite this article as:
Bueno Juan, A. Rojas Ruiz Fernando, Villabona Estupinan Santiago and V. Kouznetsov Vladimir, In Vitro Antimycobacterial Activity of New 7-Chloroquinoline Derivatives, Letters in Drug Design & Discovery 2012; 9 (2) . https://dx.doi.org/10.2174/157018012799079761
DOI https://dx.doi.org/10.2174/157018012799079761 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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