Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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In Vitro Antimycobacterial Activity of New 7-Chloroquinoline Derivatives

Author(s): Juan Bueno, Fernando A. Rojas Ruiz, Santiago Villabona Estupinan, Vladimir V. Kouznetsov.

Abstract:

The antimycobacterial activity of new 18 7-chloroquinoline derivatives, obtained from 4,7-dichloroquinoline, was evaluated against 15 Mycobacterium spp among standardized and clinical isolates using the MTT susceptibility test to obtain minimum inhibitory concentration values (MIC, μg/mL). The results suggested that 7-chloroquinoline compounds are useful leads for new anti-TB drug development. The most active compounds exhibited moderate activity with 16 μg/mL MIC values for all tested microorganisms.

Keywords: 7-Chloroquinoline derivatives, Synthesis, MDR-TB, Antimycobacterial activity, Tuberculosis (TB), Mycobacterium tuberculosis, human immunodeficiency virus (HIV), rifampin (RMP), isonicotinylhydrazine, INH, Heterocyclic systems, quinine, chloroquine, primaquine, amodiaquine

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2012
Page: [126 - 134]
Pages: 9
DOI: 10.2174/157018012799079761
Price: $58