One-Pot Three-Component Reaction for Synthesis of Highly Substituted Pyrazolo[1,2-a][1,2,4]triazole Derivatives

Author(s): Seyed S. Sajadikhah, Malek T. Maghsoodlou, Nourallah Hazeri, Sayyed M. Habibi-Khorassani.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 10 , 2011

Become EABM
Become Reviewer

Abstract:

A straightforward, simple and efficient method is described for the synthesis of pyrazolo[1,2-a][1,2,4]triazole derivates via one-pot three-component reaction between isocyanides, dialkyl acetylenedicarboxylate and 4-phenyl urazole (as a NH-acid) in acetone without using any catalyst at ambient temperature. This method offers several advantages such as high yield of products, easy work-up procedure and mild reaction conditions.

Keywords: Dialkyl acetylenedicarboxylate, isocyanide, multi-component reaction, pyrazolo[1,2-a][1,2,4]triazole, urazole, anti-inflammatory, anti-microbial, anti-hypoxic, analgesic, antibacterial

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 8
ISSUE: 10
Year: 2011
Page: [743 - 748]
Pages: 6
DOI: 10.2174/157017811799304188
Price: $58

Article Metrics

PDF: 2