Synthesis of Optically Active β-Aryloxy Alcohols and β-Arylthiol Alcohols via Asymmetric Transfer Hydrogenation Reaction

Author(s): Zhou Xu, Wei Yin, Nan Wu, Jingjing Shi, Ting Liu, Yu Wan, Hui Wu.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 10 , 2011

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Abstract:

A series of optically active β-aryloxy alcohols and β-arylthiol alcohols were synthesized directly by asymmetric transfer hydrogenation of the corresponding β-carbonyl ethers or β-carbonyl sulfides in excellent yields (up to 99%) and excellent enantioselectivity (up to 100% ee) under mild reaction conditions.

Keywords: Asymmetric transfer hydrogenation, β-aryloxy alcohols, β-arylthiol alcohols, β-ketosulfide, β-ketoether, esters, hydrogen, ketones, phenylethanone, sulfides

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2011
Page: [737 - 742]
Pages: 6
DOI: 10.2174/157017811799304197
Price: $58

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