Efficient Synthesis of Piperazinediones Using Potassium Iodide Catalysis in Aqueous Media

Author(s): Yong-Hong Wen, Xiao-Na Chen, Hui-Ling Wen, Xiao-Fang Tang.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 10 , 2011

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Abstract:

A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.

Keywords: Chloroacetamide, cyclization reaction, diketopiperazine, piperazinedione, bradykinin, antagonists, agonists, chloroacetamides, acetamide, amino acids

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2011
Page: [732 - 736]
Pages: 5
DOI: 10.2174/157017811799304098
Price: $58

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