A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.
Keywords: Chloroacetamide, cyclization reaction, diketopiperazine, piperazinedione, bradykinin, antagonists, agonists, chloroacetamides, acetamide, amino acids
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