European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.
Keywords: Impurity-A, impurity-C, exo-Granisetron (impurity-F), impurity-I, residual solvents, hydrochloride, alkylation, chemotherapy, Harmonization, azodicarboxylate
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