Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug

Author(s): Eda V.R. Vishnu, Suju Joseph, Abayee K. Srinivasana, Ramesh S. Gania, Govindabur R. Reddy, Patakokila V. Rao, Vilas H. Dahanukara, Josyula Ramanatham, Nayakanti Devanna.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 10 , 2011

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Abstract:

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

Keywords: Impurity-A, impurity-C, exo-Granisetron (impurity-F), impurity-I, residual solvents, hydrochloride, alkylation, chemotherapy, Harmonization, azodicarboxylate

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Article Details

VOLUME: 8
ISSUE: 10
Year: 2011
Page: [722 - 727]
Pages: 6
DOI: 10.2174/157017811799304142
Price: $58

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