Design, Synthesis and Biological Evaluation of Scutellarein Derivatives as Potential Anti-Alzheimers Disease Candidates Based on Metabolic Mechanism

Author(s): Shu-Lin Song, Nian-Guang Li, Yu-Ping Tang, Zhen-Jiang Wang, Li-Hua Qian, Hao Tang, Jin-Ao Duan.

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 1 , 2012

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Abstract:

In order to improve the metabolic stability and bioavailability of scutellarin, some derivatives of its main metabolite (scutellarein) were designed and synthesized. The antioxidant activities of these target products were assessed by measuring its scavenging capacities toward DPPH and the protective effects on H2O2-induced cytotoxicity in PC12 cells. The results showed that the target compound 7g had a higher antioxidant activity than scutellarin. Thus 7g may be considered as a novel potent anti-Alzheimers Disease drug candidate.

Keywords: Alzheimer's disease, Antioxidant, Derivative, Metabolism, Scutellarein, Scutellarin, Synthesize, anti-Alzheimer's Disease drug candidate, DPPH, cytotoxicity, PC12, Alzheimer's disease (AD), pathophysiological, neuroprotection, amyloid β protein, peroxynitrate

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2012
Page: [78 - 83]
Pages: 6
DOI: 10.2174/157018012798192946

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