Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis and Biological Evaluation of Scutellarein Derivatives as Potential Anti-Alzheimers Disease Candidates Based on Metabolic Mechanism

Author(s): Shu-Lin Song, Nian-Guang Li, Yu-Ping Tang, Zhen-Jiang Wang, Li-Hua Qian, Hao Tang and Jin-Ao Duan

Volume 9, Issue 1, 2012

Page: [78 - 83] Pages: 6

DOI: 10.2174/157018012798192946

Price: $65

Abstract

In order to improve the metabolic stability and bioavailability of scutellarin, some derivatives of its main metabolite (scutellarein) were designed and synthesized. The antioxidant activities of these target products were assessed by measuring its scavenging capacities toward DPPH and the protective effects on H2O2-induced cytotoxicity in PC12 cells. The results showed that the target compound 7g had a higher antioxidant activity than scutellarin. Thus 7g may be considered as a novel potent anti-Alzheimers Disease drug candidate.

Keywords: Alzheimer's disease, Antioxidant, Derivative, Metabolism, Scutellarein, Scutellarin, Synthesize, anti-Alzheimer's Disease drug candidate, DPPH, cytotoxicity, PC12, Alzheimer's disease (AD), pathophysiological, neuroprotection, amyloid β protein, peroxynitrate


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy