Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

Author(s): Ling-Ling Fan, Ning Huang, Rui-Ge Yang, Shu-Zhen He, Liu-Meng Yang, Hui Xu, Yong-Tang Zheng.


In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 μg/mL, and TI values of 63.76 and 53.60, respectively.

Keywords: 5,6-Dihydro-indolo[1,2-a]quinoxaline, Acquired immunodeficiency syndrome, Human immunodeficiency virus-1, Inhibitor, AIDS, quinoxaline, HIV-1, Syncytia Assay, MTT-based Cytotoxicity Assay, TCID50, calf serum, Anti-HIV-1 Activity Assay, HIV-1 IIIB, Reed and Muench method

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Article Details

Year: 2012
Page: [44 - 47]
Pages: 4
DOI: 10.2174/157018012798193026