Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antioxidant Activity of Resveratrol Analogs

Author(s): Natalia Oliveira Calil, Gustavo Senra Goncalves de Carvalho, Danielle Cristina Zimmermann Franco, Adilson David da Silva, Nadia Rezende Barbosa Raposo.

Abstract:

This study evaluated the antioxidant activity of five resveratrol analogs by relating the activity of the molecule with its chemical structure. The five resveratrol analogs were synthesized and the antioxidant activity was evaluated using the DPPH method. The resveratrol was used as the reference standard. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The antioxidant activity of resveratrol analogs was considered statistically different, with the analog A which showed activity superior to the others. The five analogs presented lower antioxidant activity than the reference standard (p < 0.001). According to the findings, hydroxylation was the molecular modification that gave the best evaluated antioxidant activity result. Resveratrol analogs may have an important antioxidative activity, but with the one with the higher IC50 was presented by the natural compound.

Keywords: Antioxidants, Chemical Synthesis, 2, 2-diphenyl-1-picrylhydrazyl, Hydroxylation, Resveratrol, Structure-Activity Relationship, ANOVA, analog A, IC50, Flavonoids, RNS, Alzheimer's disease, cardioprotective, anticancer, MAO-A

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2012
Page: [8 - 11]
Pages: 4
DOI: 10.2174/157018012798192928