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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 9
ISSUE: 1
DOI: 10.2174/157018012798192928









Antioxidant Activity of Resveratrol Analogs

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Author(s): Natalia Oliveira Calil, Gustavo Senra Goncalves de Carvalho, Danielle Cristina Zimmermann Franco, Adilson David da Silva and Nadia Rezende Barbosa Raposo
Pages 8-11 (4)
Abstract:
This study evaluated the antioxidant activity of five resveratrol analogs by relating the activity of the molecule with its chemical structure. The five resveratrol analogs were synthesized and the antioxidant activity was evaluated using the DPPH method. The resveratrol was used as the reference standard. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The antioxidant activity of resveratrol analogs was considered statistically different, with the analog A which showed activity superior to the others. The five analogs presented lower antioxidant activity than the reference standard (p < 0.001). According to the findings, hydroxylation was the molecular modification that gave the best evaluated antioxidant activity result. Resveratrol analogs may have an important antioxidative activity, but with the one with the higher IC50 was presented by the natural compound.
Keywords:
Antioxidants, Chemical Synthesis, 2, 2-diphenyl-1-picrylhydrazyl, Hydroxylation, Resveratrol, Structure-Activity Relationship, ANOVA, analog A, IC50, Flavonoids, RNS, Alzheimer's disease, cardioprotective, anticancer, MAO-A
Affiliation:
NUPICS, Faculdade de Farmacia, Universidade Federal de Juiz de Fora, Juiz de Fora, M.G. 36036-330, Brazil.