Multitarget Antithrombotic Drugs

Author(s): Milos Ilic , Danijel Kikelj , Janez Ilas .

Journal Name: Current Topics in Medicinal Chemistry

Volume 11 , Issue 22 , 2011

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Abstract:

Thromboembolic disorders are still the leading causes of morbidity and mortality in developed societies. Therefore, prophylaxis and treatment of arterial and venous thrombosis are among the main therapeutic challenges nowadays. Simultaneous action on several targets involved in pathology of thrombosis offers potential advantages compared to existing drugs which were developed as selective modulators of single targets. The review focuses on dual inhibitors of coagulation enzymes, dual antiaggregatory compounds exerting their action on different combinations of platelet targets, as well as on anticoagulant/antiaggregatory compounds which interfere with at least one target involved in blood coagulation and at least one target engaged in the process leading to platelet aggregation.

Keywords: Anticoagulants, antiplatelet, antithrombotics, dual inhibitors, multitarget drugs, prophylaxis, anticoagulant/antiaggregatory compounds, haemostasis, antiplatelet activity, antiaggregatory drugs, calcium ions, coagulation factors, pharmacokineticproperties, predictable pharmacokinetics, thromboxane synthase

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Article Details

VOLUME: 11
ISSUE: 22
Year: 2011
Page: [2834 - 2848]
Pages: 15
DOI: 10.2174/156802611798184364
Price: $58

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