Damnacanthal-Induced Anti-Inflammation is Associated with Inhibition of NF-κB Activity
Thararat Nualsanit, Pleumchitt Rojanapanthu, Wandee Gritsanapan, Thiwanporn Kwankitpraniti, Kyung-Won Min and Seung Joon Baek
Affiliation: University of Tennessee, College of Veterinary Medicine, Department of Biomedical and Diagnostic Sciences, 2407 River Dr. Knoxville, TN 37996, USA.
Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this antiinflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-κB (NF-κB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases.
Keywords: COX-2, damnacanthal, iNOS, Morinda citrifolia L. (Rubiaceae), NF-κB, Reverse Transcription-Polymerase Chain Reaction, LPS, Nonsteroidal anti-inflammatory drug, Tumor necrosis factor alpha, Inducible nitric oxide synthase
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