Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX
USA

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Vitamin D and Lung Cancer

Author(s): Helga Rhein.

Abstract:

Lung cancer is one of the most common cancers but treatment has limited success and survival rates remain low. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has anti-proliferative and pro-apoptotic actions in lung carcinoma cell lines in vitro. Vitamin D deficiency is associated with poor prognosis in lung cancer, and lung cancer survival varies according to vitamin D receptor genotype. Randomized controlled trials should be performed to determine whether vitamin D supplementation might have a role as an adjunct to conventional treatments for lung cancer.

Keywords: Vitamin D, lung cancer, incidence, mortality, chemotherapy, radiotherapy, NSCLC, anti-angiogenic, pro-apoptotic, vitamin D supplementation

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2011
Page: [440 - 443]
Pages: 4
DOI: 10.2174/157339811798072649
Price: $58