Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides

Author(s): Nguyen-Hai Nam, Phan Thi Phuong Dung, Doan Thanh Hieu, Le Hoang, Tran Thi Hien, Tran The Cuong, Phan Dinh Chau.

Journal Name: Medicinal Chemistry

Volume 7 , Issue 6 , 2011

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Abstract:

A series of simple (6-substitutedbenzothiazol-2-yl)acrylamides was synthesized and evaluated for cytotoxicity and antimicrobial effects. All six compounds displayed very significant cytotoxicity against four cancer cell lines tested including A549 (a human lung cancer cell line), Hela (a human ovarian cancer cell line), MCF7 (a human breast cancer cell line), and even MCF7-ADR (adriamycin-resistant human breast cancer cell line), with IC50 values in microgram/ml range and as low as 0.66 μg/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger.

Keywords: kwd, Benzothiazole, cytotoxicity, synthesis, acrylamides, (6-substitutedbenzothiazol-2-yl), and antimicrobial effects, antifungal effects, Apergillus niger, nucleophilic, 2-aminobenzothiazole

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2011
Page: [727 - 731]
Pages: 5
DOI: 10.2174/157340611797928280
Price: $58

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