Abstract
1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone.
The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).
Keywords: Antioxidant activity, Pyrazoles, Semicarbazides, 1, 2, 4-Triazoles, Trolox, Tongguan capsule (TGC), coronary heart disease (CHD), Traditional Chinese Medicine (TCM), Molecular Mechanism, Computational Pharmacology Methods, Salvia, Gaussin distribution, Lipinski's “rule of five”, Astragalus
Letters in Drug Design & Discovery
Title: Antioxidant Evaluation of Some Semicarbazide, 1,2,4-Triazolone and Pyrazolone Derivatives
Volume: 8 Issue: 10
Author(s): Monika Pitucha and Renata Nowak
Affiliation:
Keywords: Antioxidant activity, Pyrazoles, Semicarbazides, 1, 2, 4-Triazoles, Trolox, Tongguan capsule (TGC), coronary heart disease (CHD), Traditional Chinese Medicine (TCM), Molecular Mechanism, Computational Pharmacology Methods, Salvia, Gaussin distribution, Lipinski's “rule of five”, Astragalus
Abstract: 1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone.
The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).
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Cite this article as:
Pitucha Monika and Nowak Renata, Antioxidant Evaluation of Some Semicarbazide, 1,2,4-Triazolone and Pyrazolone Derivatives, Letters in Drug Design & Discovery 2011; 8 (10) . https://dx.doi.org/10.2174/157018011797655188
DOI https://dx.doi.org/10.2174/157018011797655188 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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