Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4Hpyrido[ 1,2-a]pyrimidin-4-one Derivatives as Antimicrobial Agents

Author(s): Byregowda Krishnamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Byregowda Raghava, Kanchugarakoppal S. Rangappa.


A series of novel 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one sulfonamide and carboxamide derivatives were synthesized in good yield. The synthesized compounds were characterized by 1H-NMR, FTIR and elemental analysis. All the synthesised compounds were screened for their in vitro antimicrobial activity by agar well diffusion and micro dilution method against standard strains of Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus epidermidis 435), and Gram-negative (Xanthomonas campestris 7903 and Pseudomonas aeruginosa MTCC 7908) bacteria. Compound 7a and compound 8d with dichloro substitution among sulphonamide and carboxamide series respectively showed potent inhibitory activity.

Keywords: Acid chlorides, Antimicrobial activity, 2-Aminopyridine, Phosphorous oxychloride, Piperazine, Sulfonyl chlorides, carboxamide, sulfonamide, H-NMR, FTIR, Staphylococcus epidermidis, Pseudomonas aeruginosa, MTCC, Antimicrobial, antitubercular, beta-lactam derivatives

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Article Details

Year: 2011
Page: [988 - 995]
Pages: 8
DOI: 10.2174/157018011797655304
Price: $58