Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

Author(s): Z.-J. Huang, Y. Zeng, P. Lan, P.-H. Sun, W.-M. Chen.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 13 , 2011

Abstract:

Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Keywords: Berberine, structural modification, biological activities, isoquinoline alkaloid, Chinese herbs, Coptidis Rhizome, antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, antimalaria

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Article Details

VOLUME: 11
ISSUE: 13
Year: 2011
Page: [1122 - 1129]
Pages: 8
DOI: 10.2174/138955711797655362
Price: $58

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