Autoantibodies as Biomarkers for ANCA-Associated Vasculitides

Author(s): Cees G.M. Kallenberg.

Journal Name: Current Immunology Reviews

Volume 7 , Issue 4 , 2011

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Abstract:

Both PR3-ANCA and MPO-ANCA are highly sensitive and specific markers for the ANCA-associated vasculitides (AAV), in particular granulomatosis with polyangiitis and microscopic polyangiitis. This close association suggests a pathogenic role of the autoantibodies. In vitro and in vivo experimental data strongly support such a role, particularly for MPO-ANCA. As pathogenic autoantibodies ANCA could serve as biomarkers for AAV. Longitudinal observations indeed prove that MPO-ANCA could serve as a biomarker for AAV although being not perfect. For PR3- ANCA, data are less convincing as some studies found a fair correlation between changes in levels of PR3-ANCA and disease activity of the AAV, but others found not. This could be due to methodological shortcomings but also to inherent differences in pathogenicity between MPO-ANCA and PR3-ANCA. More studies are needed to solve this question.

Keywords: PR3-ANCA, MPO-ANCA, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), proteinase 3, ANCA-associated vasculitides, Idiopathic crescentic glomerulonephritis, c-ANCA, P-ANCA

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [407 - 414]
Pages: 8
DOI: 10.2174/157339511797535072
Price: $58

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