The Need for Diagnostic Criteria in Systemic Vasculitis

Author(s): Ravi Suppiah, Joanna Robson, Neil Basu, Raashid Luqmani.

Journal Name: Current Immunology Reviews

Volume 7 , Issue 4 , 2011

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Abstract:

There are currently no diagnostic criteria for the systemic vasculitides. Due to the heterogeneous and non specific manner that vasculitis can present there is often a delay in diagnosis which translates to increase morbidity and mortality. The current disease definitions and classification criteria are often misapplied as diagnostic criteria, but evaluation of this has shown that they do not perform satisfactorily for this purpose. We discuss the CHCC definitions, the ACR classification criteria and the EMEA algorithm which is needed to bridge the inconsistency between the two. We also evaluate the FVSG proposal for polyarteritis nodosa, and attempts of the Behcets disease community to develop diagnostic criteria. We provide a brief summary of how a diagnosis of vasculitis is currently made, describe how increased understanding of disease mechanisms has identified biomarkers which aid diagnosis, and describe how clinically applicable diagnostic criteria could be developed.

Keywords: Vasculitis, ANCA, diagnosis, systemic vasculitides, polyarteritis nodosa, Microscopic polyangiitis, Myeloperoxidase, Proteinase 3, Anti-neutrophil cytoplasm antibodies

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [394 - 401]
Pages: 8
DOI: 10.2174/157339511797535135
Price: $58

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