Copper-Catalyzed Direct Amination of Halo(hetero)arenes with Sodium Azide as the Amino Source

Author(s): S. Messaoudi, J.-D. Brion, M. Alami.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 8 , Issue 4 , 2011

Become EABM
Become Reviewer


In the synthesis of primary (hetero)aryl amines through copper-catalysis, the ammonia surrogates or aqueous ammonia nucleophilic partners can be replaced by sodium azide. Recent efforts in copper-mediated transformation of (hetero)aryl halides to (hetero) aryl amines using azide anion as the amino source are discussed in these highlights.

Keywords: Amination, Anilines, Aminoheterocycles, Sodium azide, copper, copper-catalysis

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2011
Page: [448 - 454]
Pages: 7
DOI: 10.2174/157019311797440236
Price: $58

Article Metrics

PDF: 4