The Therapeutic Potential of Stem Cells in Amyotrophic Lateral Sclerosis

Author(s): Dinko Mitrecic, Charles Nicaise, Srecko Gajovic, Roland Pochet.

Journal Name: Current Signal Transduction Therapy

Volume 6 , Issue 3 , 2011

Submit Manuscript
Submit Proposal

Abstract:

Stem cells – based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell applications and their effects. Here we summarize various therapeutic approaches with respect to different sources of stem cells and diverse administration routes. Observed slow down of the disease progression and acceptable side effects emerge as the solid basis for optimism regarding the potential of the stem cell therapy for ALS.

Keywords: cell transplantation, administration route, regenerative medicine, amyotrophic lateral sclerosis, stem cells, therapy, neural stem cells, mesenchymal stem cells, growth factors, rats, mice, clinical trial, delivery, dose, iPS, cell replacement

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 6
ISSUE: 3
Year: 2011
Page: [341 - 346]
Pages: 6
DOI: 10.2174/157436211797483985
Price: $58

Article Metrics

PDF: 2