Abstract
Stem cells – based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell applications and their effects. Here we summarize various therapeutic approaches with respect to different sources of stem cells and diverse administration routes. Observed slow down of the disease progression and acceptable side effects emerge as the solid basis for optimism regarding the potential of the stem cell therapy for ALS.
Keywords: cell transplantation, administration route, regenerative medicine, amyotrophic lateral sclerosis, stem cells, therapy, neural stem cells, mesenchymal stem cells, growth factors, rats, mice, clinical trial, delivery, dose, iPS, cell replacement
Current Signal Transduction Therapy
Title: The Therapeutic Potential of Stem Cells in Amyotrophic Lateral Sclerosis
Volume: 6 Issue: 3
Author(s): Dinko Mitrecic, Charles Nicaise, Srecko Gajovic and Roland Pochet
Affiliation:
Keywords: cell transplantation, administration route, regenerative medicine, amyotrophic lateral sclerosis, stem cells, therapy, neural stem cells, mesenchymal stem cells, growth factors, rats, mice, clinical trial, delivery, dose, iPS, cell replacement
Abstract: Stem cells – based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell applications and their effects. Here we summarize various therapeutic approaches with respect to different sources of stem cells and diverse administration routes. Observed slow down of the disease progression and acceptable side effects emerge as the solid basis for optimism regarding the potential of the stem cell therapy for ALS.
Export Options
About this article
Cite this article as:
Mitrecic Dinko, Nicaise Charles, Gajovic Srecko and Pochet Roland, The Therapeutic Potential of Stem Cells in Amyotrophic Lateral Sclerosis, Current Signal Transduction Therapy 2011; 6 (3) . https://dx.doi.org/10.2174/157436211797483985
DOI https://dx.doi.org/10.2174/157436211797483985 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
Current Medicinal Chemistry A Protective Role of Translocator Protein in Alzheimer’s Disease Brain
Current Alzheimer Research Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative Stress-Related Diseases
Current Pharmaceutical Design Cellular Strategies to Combat Protein Misfolding: Intricate Role of Hsp70 in Stress Management
Current Chemical Biology Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences Towards A Multimodal Treatment of Depression: A Minireview on the Potential Role of Antibiotics
Mini-Reviews in Medicinal Chemistry Non-Antidepressant Pharmacological Treatment of Obsessive Compulsive Disorder: A Comprehensive Review
Current Clinical Pharmacology Meet Our Editorial Board Member
Recent Patents on CNS Drug Discovery (Discontinued) Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)
Current Inorganic Chemistry (Discontinued) Neuroprotective Potential of Adenyl Cyclase/cAMP/CREB and Mitochondrial CoQ10 Activator in Amyotrophic Lateral Sclerosis Rats
Current Bioactive Compounds Potential Roles of HDAC Inhibitors in Mitigating Ischemia-induced Brain Damage and Facilitating Endogenous Regeneration and Recovery
Current Pharmaceutical Design Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders
Current Gene Therapy Denouement of Chemicals on Amyotrophic Lateral Sclerosis: Is Green Chemistry the Answer
Medicinal Chemistry Editorial [Hot Topic: The Pineal Hormone Melatonin in Health and Disease (Guest Editors: Charanjit Kaur)]
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Mesenchymal Stem Cells as Mediators of Neural Differentiation
Current Stem Cell Research & Therapy Extraction, Characterization and In Vivo Neuromodulatory Activity of Phytosterols from Microalga Dunaliella Tertiolecta
Current Medicinal Chemistry Glycogen Synthase Kinase-3: A Potential Target for Drug Discovery in the Treatment of Neurodegenerative Disorders
Current Enzyme Inhibition Neurotrophic Effects of the Peptide NAP: A Novel Neuroprotective Drug Candidate
Current Alzheimer Research MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological and Pathological Responses
MicroRNA The Role of Retinoids in the Adult Nervous System and their Therapeutic Potential
Mini-Reviews in Medicinal Chemistry