Natural Products with Antitumor Activity from Endophytic Fungi

Author(s): L.-W. Wang, Y.-L. Zhang, F.-C. Lin, Y.-Z. Hu, C.-L. Zhang.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 12 , 2011

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Endophytic fungi are a seemingly inexhaustible source of novel bioactive natural products. Currently, more than 140 fungal metabolites have shown confirmed activity in tumor cell line bioassays. We present the chemical structures of these antitumor metabolites, their corresponding fungal endophytes and host plants, and the activities they exhibited, and briefly discuss some of their action mechanisms. This review emphasizes the role of endophytic fungi as an important source of leads for drug discoveries.

Keywords: Antitumor activity, fungal endophytes, natural products, secondary metabolites, Endophytic fungi, tumor cell line, A549, ACHN, BC-1, BEL-7404, CPT, FPTase

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Article Details

Year: 2011
Page: [1056 - 1074]
Pages: 19
DOI: 10.2174/138955711797247716
Price: $58

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