Recent Advances in the Field of 16-Membered Macrolide Antibiotics

Author(s): W. Cui, S. Ma.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 12 , 2011

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Abstract:

The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.

Keywords: 16-membered macrolides, structural flexibility, mycarose moiety, antimicrobial properties, resistant strains, resistance mechanism, tylosin, leucomycin, bacterial resistance, gastrointestinal

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Article Details

VOLUME: 11
ISSUE: 12
Year: 2011
Page: [1009 - 1018]
Pages: 10
DOI: 10.2174/138955711797247734
Price: $58

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