Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives

Author(s): L. Stavitskaya, A. Coop.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 11 , Issue 12 , 2011

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Abstract:

The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.

Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position

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Article Details

VOLUME: 11
ISSUE: 12
Year: 2011
Page: [1002 - 1008]
Pages: 7
DOI: 10.2174/138955711797247752
Price: $58

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