The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.
Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position
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