Cytotoxicity Study on Some Synthetic Aromatic Esters of 4-Demethyl-4-deoxypodophyllotoxin

Juan-Juan      Wang; Hong-Jin      Han; Guang-Zhi      Zeng; Hui      Xu; Ning-Hua      Tan

Abstract

To search for potential anti-cancer analogs, 16 aromatic esters of 4-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.

Keywords: Aromatic ester, Cytotoxicity, Deoxypodophyllotoxin, Aromatic Esters, Podophyllotoxin, antiproliferative, antitumor, carboxylalkyl, MS, 1H NMR, HRMS, Reed-Muench method

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Letters in Drug Design & Discovery

Title: Cytotoxicity Study on Some Synthetic Aromatic Esters of 4-Demethyl-4-deoxypodophyllotoxin

Volume: 8 Issue: 9

Author(s): Juan-Juan Wang, Hong-Jin Han, Guang-Zhi Zeng, Hui Xu and Ning-Hua Tan

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Keywords: Aromatic ester, Cytotoxicity, Deoxypodophyllotoxin, Aromatic Esters, Podophyllotoxin, antiproliferative, antitumor, carboxylalkyl, MS, 1H NMR, HRMS, Reed-Muench method

Abstract: To search for potential anti-cancer analogs, 16 aromatic esters of 4-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.

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Wang Juan-Juan, Han Hong-Jin, Zeng Guang-Zhi, Xu Hui and Tan Ning-Hua, Cytotoxicity Study on Some Synthetic Aromatic Esters of 4-Demethyl-4-deoxypodophyllotoxin, Letters in Drug Design & Discovery 2011; 8 (9) . https://dx.doi.org/10.2174/157018011797200849