Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Use of Physicochemical and Topological Parameters in Estimating Anti-Cancer Activity of Benzothiazole Derivatives

Author(s): Deepali Gupta, Basheerulla Shaik, Jyoti Singh, Neelu Singh, Vijay K. Agrawal.

Abstract:

Several physicochemical and topological descriptors used for estimating anti-cancer activity of benzothiazole derivatives indicated that the use of physicochemical parameters alone yield most appropriate model for modeling the activity.

Keywords: Anticancer, Benzothiazole derivatives, Cross-validation, Multiple linear regression, QSAR, DRAGON softwares, Topological Parameters, Physicochemical, NCSS software, Balaban, Molar volume, Molar refractivity, Index of Refraction, Surface tension, Polarizabilty

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2011
Page: [850 - 856]
Pages: 7
DOI: 10.2174/157018011797200759
Price: $58