Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines

Author(s): Ashish Sharma, Tabreskhan Pathan, Rhea Mohan, C. S. Ramaa.

Abstract:

Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.

Keywords: Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2011
Page: [843 - 849]
Pages: 7
DOI: 10.2174/157018011797200812
Price: $58