Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities

Author(s): Gulhan Turan-Zitouni, Yusuf Ozkay, Ahmet Ozdemir, Zafer Asim Kaplancikli, Mehlika Dilek Altintop.

Abstract:

Some benzothiazole derivatives bearing piperazine and dithiocarbamate moieties were synthesized in order to investigate their anticancer activity. The structures of the obtained compounds were confirmed by spectral data and elemental analysis. Synthesized compounds were evaluated for their anticancer activity at the National Cancer Institute against a panel of approximately 60 different human tumor cell lines derived from nine neoplastic cancer types. Compound 3f was found to be significantly active against all cancer types in single concentration assay and selected for second step which includes five concentration assays. In the second step, it exhibited very significant activity on melanoma (LOX IMVI) cell line.

Keywords: Anticancer activity, Benzothiazole, Dithiocarbamate, (LOX IMVI) cell line, Melonoma, Piperazine, Raf kinase, flash chromatography separations (FC), IR spectra, DMSO-d6 solutions, TMS, Bruker apparatus, Chemical shift

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Article Details

VOLUME: 8
ISSUE: 9
Year: 2011
Page: [830 - 837]
Pages: 8
DOI: 10.2174/157018011797200786
Price: $58