Synthesis, Antibacterial and Antifungal Activities of Some Carbazole Dithiocarbamate Derivatives
Ahmet Cagri Karaburun,
Zafer Asim Kaplancikli,
In this study, we aimed at the synthesis of new N,N-disubstituted dithiocarbamoic acid, 2-[(9-ethyl-9Hcarbazol- 3-yl)amino]-2-oxoethyl esters and their antimicrobial evaluations. The chemical structures of the compounds were elucidated by IR, 1H NMR, 13C NMR, MS spectral data and elemental analysis. The antibacterial and antifungal activities of the synthesised derivatives were tested against Gram (+), Gram (-) bacteria and yeasts such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans (two strains), Candida glabrata, Candida tropicalis, Candida parapsilosis and Saccharomyces cerevisiae using a microbroth dilution technique. The results showed that the compounds displayed different degrees of antimicrobial activities; however, when compared almost all of the compounds displayed better antifungal activities (minimum inhibitory concentrations, 312.5- > 1250 μg mL-1).
Keywords: Antibacterial activity, Antifungal activity, Carbazole, Dithiocarbamate, Dithiocarbamate fungicides, nonselective pestici, Cladosporium cucumerinum, phytoalexins, conjugated compounds, aromatic compounds, heterocyclic compounds, N,N-disubstituted dithiocarbamoic acid, Shimadzu 8400S spectrophotometer, tetramethylsilane (TMS)
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