Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

Title: Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives

Volume: 8 Issue: 8

Author(s): Kamal Sweidan, Jorn Engelmann, Rajendra Joshi, Mohammad S. Mubarak and Mustafa M. El-Abadelah

Affiliation:

Keywords: 5-bis(thioethyl)methylenebarbiturates, 1,3-diazamethylene barbiturates, 1,3-dimethylbarbituric acid, azaheterocycles, solid-state 13C-NMR, pyrimidine, trioxopyrimidine, nucleophilic, amines, alkylation

Abstract: The reaction of 1,3-dimethyl-5-bis(thioethyl)methylene barbituric acid (2) with various vic-diamines leads to the formation of the respective 1,3-diazamethylene barbiturate derivatives 3 (a-f) in high yields. Solid-state 13C-NMR, MS and IR spectral data were employed for the characterization of these compounds. Antimicrobial screening revealed that none of the newly synthesized compounds showed appreciable antibacterial activity.

Cite this article as:

Sweidan Kamal, Engelmann Jorn, Joshi Rajendra, S. Mubarak Mohammad and M. El-Abadelah Mustafa, Synthesis of Some Cyclic Methylene 1,3-Diaza Barbiturates Derivatives, Letters in Organic Chemistry 2011; 8 (8) . https://dx.doi.org/10.2174/157017811797249353