Immobilized Cu(I) on Organic-Inorganic Hybrid Material: An Effective and Reusable Catalyst for Biginelli Reaction

Title: Immobilized Cu(I) on Organic-Inorganic Hybrid Material: An Effective and Reusable Catalyst for Biginelli Reaction

Volume: 8 Issue: 8

Author(s): Xiao L. Zhang, Min Wang and Lei Wang

Affiliation:

Keywords: β-Keto ester, Biginelli reaction, Heterogeneous catalyst, Immobilization of Cu(I), Organic, inorganic hybrid material, Urea (thiourea), Dihydropyrimidin, alkaloids, aromatic aldehyde, hybrid catalysts

Abstract: The immobilized Cu(I) on organic-inorganic hybrid material was prepared and used as effective catalyst for the Biginelli reaction. In the presence of immobilized copper catalyst, aromatic aldehydes reacted with β-keto ester and urea (or thiourea) smoothly to generate the corresponding Biginelli products in good to excellent yields without any additive. The work-up procedure is very simple and practical. Furthermore, the silica-supported Cu(I) could be recovered and recycled for eight consecutive trials without significant loss of its reactivity.

Cite this article as:

L. Zhang Xiao, Wang Min and Wang Lei, Immobilized Cu(I) on Organic-Inorganic Hybrid Material: An Effective and Reusable Catalyst for Biginelli Reaction, Letters in Organic Chemistry 2011; 8 (8) . https://dx.doi.org/10.2174/157017811797249425