A Simple and Efficient Method for Trifluoroacetylation of Arylamines Using Trifluoroacetic Acid and Triphosgene

Author(s): Ki-Jong Han, Misoo Kim.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 8 , 2011

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Abstract:

A simple and efficient one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid and triphosgene is reported. A mixed trifluoroacetic anhydride generated in situ reacts with a variety of arylamines to give the corresponding trifluroacetamides in high yields.

Keywords: Trifluoroacetylation, trifluoroacetamides, trifluoroacetic acid, arylamines, triphosgene, N-trifluoroacetylimidazole, N-(trifluoroacetoxy)succinimide, benzotriazole, poly-phosphoric acid, trimethylsilylester

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Article Details

VOLUME: 8
ISSUE: 8
Year: 2011
Page: [559 - 561]
Pages: 3
DOI: 10.2174/157017811797249317
Price: $58

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