Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines

Author(s): Chunyan Xu, Chuanjie Cheng, Hongtao Liu, Bo Liu.

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 8 , 2011

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Abstract:

Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.

Keywords: 2-methoxy-4-substituted pyrimidine, azaheterocycles, chemoselective synthesis, diazotization, hydrolysis, antibiotics, vitamins, alkaloids, heterocyclic pyrimidines, catalysis

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Article Details

VOLUME: 8
ISSUE: 8
Year: 2011
Page: [545 - 548]
Pages: 4
DOI: 10.2174/157017811797249371
Price: $65

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